Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated
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چکیده
منابع مشابه
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.
Presently, nothing is known about the function of the Ras-related protein Rheb. Since Rheb shares significant sequence identity with the core effector domains of Ras and KRev-1/Rap1A, it may share functional similarities with these two structurally related, yet functionally distinct, small GTPases. Furthermore, since like Ras, Rheb terminates with a COOH terminus that is likely to signal for fa...
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Over the past several years, a large superfamily of monomeric GTP-binding proteins structurally related to the ras oncogene proteins has been described (1-4). The number of members of this superfamily identified has increased dramatically in recent years, and the number of descriptive terms or names used to denote these proteins has increased almost as dramatically as well. During the recent FA...
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The Ras superfamily of small guanosine triphosphatases (GTPases) comprise over 150 human members (Table S1 in supplementary material), with evolutionarily conserved orthologs found in Drosophila, C. elegans, S. cerevisiae, S. pombe, Dictyostelium and plants (Colicelli, 2004). The Ras oncogene proteins are the founding members of this family, which is divided into five major branches on the basi...
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Ras guanosine triphosphatases (GTPases) regulate signaling pathways only when associated with cellular membranes through their C-terminal prenylated regions. Ras proteins move between membrane compartments in part via diffusion-limited, fluid phase transfer through the cytosol, suggesting that chaperones sequester the polyisoprene lipid from the aqueous environment. In this study, we analyze th...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1993
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2890349